DTC- Depository Trust Company Daniel Guidotti 14 years ago DTC- Depository Trust CompanyDepository for securities that accepts custody of eligible securities. It is a user owned entity that handles transactions of these securities, maintains books to record these transactions and enables withdrawals.Recommended for you:DTCC- Depository Trust & Clearing CorporationMBS DepositoryHolding Company Depository Receipt – HOLDRDerivative Product Company